Eluent Delivery

The UHPLC Pump P 6.1L with LPG configuration has a new LPG valve for precise mixing efficiency of up to four eluents at up to 1000 bar. The integrated degasser prevents air bubbles in the system. A mixing chamber is mounted on each Pump P 6.1L. This can be adapted to the respective application as required.

Sample Injection

The Autosampler 6.1L can inject 0.1 – 5000 µl to have a large flexibility. Using standard vials or two microtiter plates will give you a maximum sample capacity of up to 768 samples or 108 vials. The UHPLC version can be used up to 1240 bar system backpressure.

Column Thermostating

The Column thermostat CT 2.1 is suitable for column thermostatization above and below room temperature. The instrument operates with a microprocessor controlled Peltier element for exact temperature settings.

Chromatography Data System

KNAUER ClarityChrom^® is a powerful, yet easy-to-use chromatography software for instrument control, data acquisition and data processing. It is an economical solution compared to other more complex chromatography software while still offering FDA 21 CFR Part 11 compliance.

Detection

The diode array detector DAD 6.1L covers all conceivable applications with a spectral range of 190-1000 nm. With its novel light path and optimized flow cells, it is one of the most powerful devices on the market.

The Preparative Pump 80P delivers stable and precise solvent flow for semi-preparative as well as preparative HPLC applications. By adding one or more additional pumps, binary, ternary or even quaternary high-pressure gradient systems can be easily configured. The pump can also be equipped with a binary or ternary gradient valve block to configure cost-effective low-pressure gradient systems. Exchangeable pump heads for flow rates up to 1 000 ml/min and pressures up to 40 MPa make it possible to easily optimize the pump to changing performance requirements and allow simple maintenance. Available in stainless steel or biocompatible titanium versions, the pump heads enable a wide range of applications.

The Impingement Jets Mixing (IJM) Large Production Scale Units for high flow production of nanoparticles (LNP, microemulsions, etc.) can be configured with up to eight parallel mixing units depending on the customer requirements. Each unit consists of two pumps to deliver lipid and API streams, two flowmeters for flow control, and one jet mixer.

Depending on the configuration, the predilution of the API and quenching can be performed for the combined flow of all units in one process step outside the Impingement Jets Mixing (IJM) Production Scale Unit.

The number of parallel units depends on the application. Also, the number of pumps, flowmeters, jets mixers, and pipes can be adapted to the required conditions and scale. All skids are built in a stainless steel frame on casters and are suitable for CIP cleaning procedures in pharmaceutical production.

The Impingement Jets Mixing (IJM) Large Production Scale Unit for high flow production of nanoparticles (LNP, microemulsions, etc.) consisting of:

• up to 16 KNAUER high-pressure dosing pumps 80P
• up to 16 Coriolis flow meters
• up to 8 KNAUER IJM mixers
• Inlet manifolds for lipid/ethanol mixture and mRNA/buffer mixture
• Outlet manifold for LNP solution
• Back-seal washing system
• The frame (stainless steel system 1.4301)
• Installation & familiarization by KNAUER

In addition, we offer for our customers:

• Customized Technical documentation which is order- and article-related
• Customer Service before, during, and after the setup
• Capillary customization and labeling
• FAT (Factory Acceptance Test at KNAUER Berlin)
• SAT (Site Acceptance Test at customer site)

Key Features

• Made in Germany
• Certified quality management
• Customized solutions
• Dedicated customer support

KNAUER freezing point osmometer K-7400S allows the easy and fast determination of the osmolality of various aqueous solutions. Also, the freezing point depression of the samples can be read. The proven technology of freezing point determination in combination with the robust and intelligent design of the device allows reproducible measurements. The instrument is equipped with a peltier cooler and an integrated microprocessor controlling the automated measurement. The freezing point osmometer is a standalone device that optionally can be equipped with a printer. Furthermore, the device can be controlled via the EuroOsmo 7400 software. The software automatically plots the temperature curve for each measurement and calibration and allows saving of the measured values. In addition, the data can optionally be exported into various file formats for archival storage.

The measurement specifications of the KNAUER Semi-Micro Osmometer K-7400S comply with the requirements of the European Pharmacopoeia for osmolality (Ph. Eur. 2.2.35, 10/2021) in the pharmaceutically relevant range of 0-400 mOsmol/kg.

To extract high-purity pharmaceutical active ingredients from natural products at high yields is a major challenge. This also applies to the cannabinoid sector. Simulated Moving Bed (SMB) chromatography, as a continuous LC method, sets the standard for productivity, purity and yield.

This AZURA SMB pilot system is dedicated for the continuous production of API´s. The System allows the continuous separation of mixtures of substances and extraction into two fractions. High purities and simultaneous yields of up to 100% distinguish this process from conventional preparative LC methods.

The Vacuum Pump Offers Wetted Material Combinations for Optimal Chemical Resistance

Chemically resistant liquid transfer diaphragm pump. Offers wetted material combinations for optimal chemical resistance.

Chemically resistant, oil-free diaphragm vacuum pump features PTFE heads, PTFE-coated diaphragms, and FFPM valves. An integrated self-drying system prevents the accumulation of condensates within the pump heads.  

The Diaphragm Vacuum Pump is a chemically resistant, oil-free diaphragm vacuum pump used for a wide range of laboratory applications. 

The Mini Diaphragm Vacuum Pump is a chemically resistant, oil-free diaphragm vacuum pump used for a wide range of laboratory applications. It features a PPS head, PTFE-coated diaphragm and FFPM valves.

Independent control unit for any vacuum source. Features a touchscreen control, pressure sensors, and a two-step controlled valve. Optimizes lab bench space by allowing hands-free operation of the central vacuum unit.

Based on the high level of vapor and condensate compatibility the system is perfectly suited for extremely aggressive / corrosive gases and vapors.

Make the best decisions for your kombucha.

You will be able to monitor your kombucha production process at every stage. Discover how simple, fast and effective it is to analyse your products in total autonomy.