Electrophoresis systems and consumables for nucleic acid separation, preparation and screening from small capacity to high throughput horizontal submarine gel units

Nanoscale Imaging Has Never Been Easier

Collect nanoscale topography data on your benchtop in three clicks with the nGauge AFM.

ICSPI has integrated all of the components of a traditional AFM onto a single 1 mm x 1 mm chip to create the world’s first single-chip AFM. That means that 250 AFMs can fit on the face of a penny.

The nGauge AFM uses micro-electro-mechanical systems (MEMS) to control the X, Y and Z position of the tip. This means that no alignment of lasers is required.

The nGauge is the smallest AFM in the world. Because the entire unit weighs less than 500 grams, the nGauge rejects building vibrations, so no vibration isolation table is needed, which makes the nGauge a true benchtop AFM.

What can I use AFM for?

AFM provides topographical data of a surface. That means that you can look at the shape and size of individual features, such as the pits on a DVD, or look at the particle density, such as the number of nanoparticles in an area.

The nGauge AFM can be used to investigate surfaces where the features are up to 10 µm tall. It’s tricky to pinpoint a lower limit, but the RMS noise in the vertical (z) direction of the nGauge is 1 nanometre (nm). So, depending on your requirements, features as small as 5–10 nm can be imaged with the nGauge with acceptable accuracy.

To put what a nanometer is into perspective, a quarter (25-cent coin) is about 2 cm wide. An E. coli bacterium cell is 2 µm wide (10,000× smaller than a quarter). And the diameter of a DNA helix is 2 nm (1,000× smaller than a bacterium).

The Allegro™ Peristaltic Pump family is engineered for worldwide regulatory compliance. The outstanding durability and quality of this advanced peristaltic system is second to none.

In HPLC, components of a mixture are carried through the stationary phase by the flow of a mobile phase and separation is based on differences in migration rates among the sample components. Therefore, the nature of your analytes defines not only the method but also the HPLC system.

Eluent Delivery

The UHPLC Pump P 6.1L with LPG configuration has a new LPG valve for precise mixing efficiency of up to four eluents at up to 1000 bar. The integrated degasser prevents air bubbles in the system. A mixing chamber is mounted on each Pump P 6.1L. This can be adapted to the respective application as required.

Sample Injection

The Autosampler 6.1L can inject 0.1 – 5000 µl to have a large flexibility. Using standard vials or two microtiter plates will give you a maximum sample capacity of up to 768 samples or 108 vials. The UHPLC version can be used up to 1240 bar system backpressure.

Column Thermostating

The Column thermostat CT 2.1 is suitable for column thermostatization above and below room temperature. The instrument operates with a microprocessor controlled Peltier element for exact temperature settings.

Chromatography Data System

KNAUER ClarityChrom^® is a powerful, yet easy-to-use chromatography software for instrument control, data acquisition and data processing. It is an economical solution compared to other more complex chromatography software while still offering FDA 21 CFR Part 11 compliance.

Detection

The diode array detector DAD 6.1L covers all conceivable applications with a spectral range of 190-1000 nm. With its novel light path and optimized flow cells, it is one of the most powerful devices on the market.

KNAUER freezing point osmometer K-7400S allows the easy and fast determination of the osmolality of various aqueous solutions. Also, the freezing point depression of the samples can be read. The proven technology of freezing point determination in combination with the robust and intelligent design of the device allows reproducible measurements. The instrument is equipped with a peltier cooler and an integrated microprocessor controlling the automated measurement. The freezing point osmometer is a standalone device that optionally can be equipped with a printer. Furthermore, the device can be controlled via the EuroOsmo 7400 software. The software automatically plots the temperature curve for each measurement and calibration and allows saving of the measured values. In addition, the data can optionally be exported into various file formats for archival storage.

The measurement specifications of the KNAUER Semi-Micro Osmometer K-7400S comply with the requirements of the European Pharmacopoeia for osmolality (Ph. Eur. 2.2.35, 10/2021) in the pharmaceutically relevant range of 0-400 mOsmol/kg.

Chemically resistant liquid transfer diaphragm pump. Offers wetted material combinations for optimal chemical resistance.

The Mini Diaphragm Vacuum Pump is a chemically resistant, oil-free diaphragm vacuum pump used for a wide range of laboratory applications. It features a PPS head, PTFE-coated diaphragm and FFPM valves.